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Haritha, C.
- Evaluation of Iron-induced Oxidative Stress and its Amelioration by Certain Herbs in Broilers
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1 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, IN
2 Associate Dean, College of Veterinary Science, Korutla, Andhra Pradesh, IN
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, IN
2 Associate Dean, College of Veterinary Science, Korutla, Andhra Pradesh, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 18, No 1 (2011), Pagination: 54-57Abstract
A total of 225 male broiler chicks (Cobb strain) of day-old age were randomly divided into 15 groups consisting of 15 chicks in each group. Group 1 was maintained as basal diet control and group 2 on ferrous sulfate at 0.5% in feed throughout 6 wk as iron toxic control without any treatment. Groups 3-15 were maintained on FeSO4 at 0.5% in feed for the 4 wk (28 days) of study and thereafter administered with different herbs and their combinations for the remaining 2 wk. The blood samples were drawn from wing vein at the end of 4th and 6th weeks from the birds in each group for the assay of superoxide dismutase (SOD) and catalase. Sera samples were separated from the blood for the estimation of alanine transaminase (ALT) and serum creatinine. The birds were sacrificed at the end of 6th wk and tissues were collected for the assay of reduced glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) in liver and kidney homogenates. The activities of SOD, catalase and ALT, and the concentration of TBARS and serum creatinine were increased significantly (P<0.05), while the concentration of tissue GSH was decreased significantly (P<0.05) in all the groups as compared to basal diet control and the values showed significant improvement in groups 3-15 that were treated during the last 2 weeks. It is concluded that iron induces toxicity by generating reactive oxygen species, and antioxidant herbs are useful in treating the iron-induced toxicity.Keywords
Broilers, herbs, iron, oxidative stress- Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate
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Authors
Affiliations
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, IN
2 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 03, IN
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, IN
2 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 03, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 18, No 1 (2011), Pagination: 67-69Abstract
An experimental study was conducted to evaluate the hepatotoxic effects in the progeny of dams treated with methimazole, monocrotophos (MCP) and lead acetate. Female pregnant albino rats of Wistar Kyoto strain were divided into five groups and treated as follows, from day 3 of pregnancy till weaning of pups on postnatal day (PND) 21. Group 1 served as sham control, group 2 received methimazole 0.02% in drinking water, group 3 received MCP (0.3 mg/kg orally), group 4 received lead acetate at 0.2% in drinking water and group 5 received MCP + lead acetate. Thyroid hormone profile was recorded on 14th day of gestation in dams. Eight pups from each group were euthanized on PND 21 and 90, and liver tissues were collected for analysis. Thiobarbituric acid reactive substances (TBARS), protein carbonyls and reduced glutathione (GSH) of liver were studied on PND 21 and 90, while the activities of Na+/K+ ATPase and Mg2+ATPase in the liver were studied on PND 90. T3, T4, GSH, Na+/K+ ATPase and Mg2+ATPase were significantly (P<0.05) decreased, while TBARS and protein carbonyls were significantly (P<0.05) increased in all the test groups as compared to group 1. From this study, it is concluded that both MCP and lead acetate have a possible influence on thyroid gland of dams as the thyroid profile was altered significantly and the hepatotoxic effects were comparable to those induced by methimazole.Keywords
Hepatotoxicity, lead acetate, methimazole, monocrotophos, rats- Oxidative Stress Induced by Diclofenac Alone and under the Influence of Certain Variables in Broilers
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Authors
Affiliations
1 Departments of Pharmacology and Toxicology, and College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, IN
2 Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, IN
1 Departments of Pharmacology and Toxicology, and College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, IN
2 Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 1 (2010), Pagination: 27-29Abstract
Diclofenac toxicity was studied in male broiler chicks (Cobb strain) of a day old age. The chicks were randomly divided into eight groups consisting of 10 in each group. Group 1 was kept as basal diet control (1–32 days), group 2 on basal diet for 32 days + diclofenac (0.8 mg/kg body weight I/M) on day 24, 26, 28, 30, and 32, group 3 on basal diet for 32 days + cyclophosphamide (50 mg/kg body weight I/M once daily) from day 20 to 23, group 4 on high-protein, high-calcium, low vitamin A (HPHC) diet (1–32 days), group 5 on basal diet + diclofenac + cyclophosphamide (as per the schedule), group 6 on HPHC + diclofenac (as per the schedule), group 7 on HPHC + cyclophosphamide (as per the schedule), and group 8 on HPHC + diclofenac + cyclophosphamide (as per the schedule). The activity of TBARS, SOD, and catalase revealed a significant (P <0.05) increase, while there was a significant (P < 0.05) decrease in the concentration of GSH in liver in the groups given diclofenac either alone or in combination with other variables. There was no significant difference in the diclofenac residue levels. The electron microscopy of liver revealed lesions of mild to marked severity in different combinations. It can be concluded that diclofenac has the toxic potential in poultry at subtherapeutic doses and further the toxic effects were more pronounced under the influence of immunosuppressants and HPHC diet.Keywords
Diclofenac, hepatotoxicity, high-protein high-calcium diet, oxidative stress- Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats
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Authors
Affiliations
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh - 521 102, IN
2 NTR College of Veterinary Science, Gannavaram, Krishna Dt., Andhra Pradesh - 521 102, IN
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh - 521 102, IN
2 NTR College of Veterinary Science, Gannavaram, Krishna Dt., Andhra Pradesh - 521 102, IN